ABSTRACT
Background: Thyroid cancers are neoplasms originating from follicular thyroid cells thought to be related to a number of environmental and genetic predisposing factors. HPV is one among their associated infective agent
Objective: To determine the frequency of HPV genotype-16 in infection in a group of iraqi patients with papillary thyroidcell carcinoma
Patients and Methods: A total number of 64 patients with different thyroid lesions were collected during 2008-2013. 30 have thyroid cancers, 22 benign thyroid tumors while 12 healthy thyroid tissues were used as control group. In situ hybridization [ISH] was used to localize high risk HPV- genotype 16 in these tissues
Results: Among malignant thyroid tumors 53.3% patients had HPV-16 while 27.3% HPV-16 positivity was detected in benign thyroid tumor group. None of healthy thyroid tissues revealed ISH reactions. There was 38.5% female had HPV-16, while there was 28% male had HPV-16. No significant statistical associations were noticed between the presence of HPV-16 and the age of those patients
Conclusion: Human papilloma virus genotype 16 could share a role in pathogenesis of this group of patients with thyroid cancers